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Saracatinib - CAS# 379231-04-6 Catalog No.:M7189-2 Epub 2011 Sep 22

SKU: 48361053366

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Description

Epub 2011 Sep 22

DASA-58 (40 μM) treated cells are injected into male SCID-bg/bg mice bearing PC3 tumors by IV

bolus doses of 25 mg/kg

Husbands SM

21(8):883-891

Saracatinib - CAS# 379231-04-6 Catalog No.:M7189-2 Epub 2011 Sep 22Saracatinib, CAS No. 379231 04 6, also known as AZD0530, is an orally available dual specific inhibitor of Src and Abl with anti invasive and anti tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Product

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