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and in vivo in monkeys and humans
(S)-Crizotinib was dosed to mice orally at 50
Smiles: O=C([C@@H](CC1C=C(C=CC=1)C(F)(F)F)NS(=O)(=O)C1=CC(F)=C2CNCCC2=C1)N1CCCC1
is a novel first in class
InChiKey: XVOOCQSWCCRVDY-UHFFFAOYSA-N
EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 and in vivo in monkeysEX 527, CAS No. 49843 98 3, is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20 100 M). EX 527 has been used to investigate the relationship between SIRT1 mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. Product information CAS Number:
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