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Smiles: COC1C=CC(CN2C(=O)N=C3C2=NC=NC2=C3N=CN2CC2C=CC(=CC=2)OC)=CC=1
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
1188890-41-6
0 μM in cells
which is an angiotensin-converting enzyme (ACE) inhibitor
LCL161 Size:Solid 10 mg Smiles: COC1C=CC(CN2C(=O)N=C3C2=NC=NC2=C3N=CN2CC2C=CC(=CC=2)OC)=CC=1LCL161 is a n orally bioavailable second mitochondrial derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic
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