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InChi: InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7
plasminogen activator inhibitor (PAI) 1
UNII 9JDX055TW1
5-a]pyrazine
DUN71755 is reported in WO 2012114285
ARV 771 Size:10mg solid InChi: InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7Potent BET bromodomain PROTAC degrader (DC50 = < 1nM). Comprises a BRD4 binding moiety joined by a linker to a ligand for Von Hippel Lindau (VHL) protein. Degrades BRD2 3 4 in castration resistant prostate cancer (CRPC) cell lines. Reduces androgen receptor levels and induces apoptosis in CRPC cells in vitro. Down regulates BRD4 and induces tumor regression in CRPC xenografts in mice. Also reduces leukemia burden in a mouse model. Induces degradation