CP 640186 monohydrochloride - CAS# 591778-70-0 Size:2mg solid with IC50s of 370 nM

with IC50s of 370 nM

InChiKey: MDNWOSOZYLHTCG-UHFFFAOYSA-N

BIX02189 may offer novel pharmacological tools to better characterize the role of the MEK5/ERK5 pathway in various biological systems

at hydroxylation sites in the oxygen-dependent degradation domain (ODDD)

It can also downregulate RGS4 expression in primary cortical neurons in vitro

CP 640186 monohydrochloride - CAS# 591778-70-0 Size:2mg solid with IC50s of 370 nMCP 640186 monohydrochloride, CAS No. 591778 70 0, is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. CP 640186 has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs with IC50 values of about 55 nM. This is currently the only reported potent inhibitor of mammalian ACCs. In cell cultures as well as in animal models, CP 640186 can reduce tissue malonyl CoA levels,