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TAS-116 (0-5 μM
and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors
InChi: InChI=1S/C20H24F2N4O
R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity
1186/s12974-015-0286-8
PF-04995274 0270 TAS-116 (0-5 μMPF 04995274 (PF 4995274) is a potent, high affinity, orally active and partial agonist of serotonin 4 receptor (5 HT4R) with EC50 of 0. 47 nM, 0. 36 nM, 0. 37 nM and 0. 26 nM for human 5 HT4A 4B 4D 4E, respectively. As for rat 5 HT4S 4L 4E, the EC50 is 0. 59 nM, 0. 65 nM and 0. 62 nM, respectively. PF 04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Product information CAS Number: 1331782 27 4
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