ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 ethyltransferase is a potent and selective

is a potent and selective IDH2 inhibitor

Chemical Name: 1-((2R

Smiles: CC(=O)O/N=C1/C2=CC(Cl)=CC=C2N(CC2=CC(Cl)=CC=C2Cl)C/1=O

DAPT is used at 10 µM final concentration in cell culture

Chemical Name: tert-butyl 6-(5-oxo-4-(1H-1

ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 ethyltransferase is a potent and selectiveISRIB (trans isomer), CAS No. 1597403 47 8, is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2 phosphorylation (IC50=5 nM). In cells, distinct stress conditions activate different downstream kinases, including PERK, that converge on phosphorylating the subunit of initiation factor 2 (eIF2 ). This collection of signaling pathways is termed the integrated stress response (ISR). Trans ISRIB is a potent and