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b-AP15 (NSC686852)
is a selective and reversible inhibitor of IκB kinase 2 (IKK2) that may target osteoclastogenesis
Formula: C21H21ClF2O4S
ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays
AUY-922 (500 nM) in combination with NSC 118218 more effectively induces apoptosis in cells in co-culture than either drug alone
PF-3845 RB597 b-AP15 (NSC686852)PF 3845 is a fatty acid amide hydrolase (FAAH) inhibitor, and acts in the nervous system to reverse LPS induced tactile allodynia in mice. PF 3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. Treatment with PF3845 inactivated FAAH activity and enhanced the AEA levels in the brain. It reduced neurodegeneration in the dentate gyrus, and up regulated the expression of Bcl 2 and
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