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InChi: InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22
4(11):1948-62
PubMed Central PMCID: PMC3500996
Bloedon LT
inhibits prostate cancer cell growth in vitro and tumor growth in vivo
CVT-313 - CAS# 199986-75-9 0425 InChi: InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22CVT 313, CAS No. 199986 75 9, is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT 313 has an IC50 of 0. 5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT 313 had no effect on other, nonrelated ATP dependent serine threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT 313 with the IC50 for growth arrest ranging from 1. 25 to
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