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7-tetrahydrothieno[3
Roderick HL
HCI-2509 was administered through IP injection at 25-30 mg/kg once per day in xenografts models
The proinflammatory marker MHC-II expressed on myeloid cells but not neurons also appears to be less abundant in confocal sections in G2019S+ rats treated with PF-06447475
InChi: InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11
GS-444217 LSB 7-tetrahydrothieno[3GS 444217 (ASK1 IN 1) is a potent, selective, orally available and ATP competitive inhibitor of ASK1 (apoptosis signal regulating kinase 1) with IC50 of 2. 87 nM. Product information CAS Number: 1262041 49 5 Molecular Weight: 411. 46 Formula: C23H21N7O Synonym: ASK1 IN 1 Chemical Name: 4 (4 Cyclopropyl 1H imidazol 1 yl) N (3 (4 cyclopropyl 4H 1,2,4 triazol 3 yl)phenyl)picolinamide Smiles: O=C(NC1=CC(=CC=C1)C1=NN=CN1C1CC1)C1=CC(=CC=N1)N1C=C(N=C1)C1CC1
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