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Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor
1186/1744-9081-8-43
1998 May 22
Chemical Name: 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2
SB-743921 HCl Catalog No.:M7949-2 3% of controlSB 743921 is a synthetic small molecule with potential antineoplastic properties. SB 743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Product information CAS Number: 940929 33 9