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Formula: C40H52Cl2N8O6
CX-4945 can potentiate senescence by blocking tumour progression in Ptenpc -/- mice
It has no activity at other histone methyltransferases
GSK343 was used at 10-50 µM final concentration in vitro and in cellular assays
7 µM) and inducing HIF-1α and HIF-2α expression in mice
MC1568 - Class IIa HDAC Inhibitor. CAS# 852475-26-4 0318 Formula: C40H52Cl2N8O6MC1568, CAS No. 852475 26 4, is a potent and selective inhibitor of class IIa histone deacetylases (HDACs), with IC50 of 100 nM for maize HD1 A. It is 34 fold more selective for HD1 A than HD1 B, 176 fold more selective for class I HDACs. It exhibits tissue selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. It arrests myogenesis through the
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