RA190 - Ubiquitin Receptor RPN13/ADRM1 Inhibitor. CAS# 1617495-03-0 60256 KD =53±2 nM) with outstanding

KD =53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets)

InChiKey: GACQNUHFDBEIQH-HNNXBMFYSA-N

23(7):769-81

Chemical Name: 4-amino-1-((2R

Chemical Name: (Z)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1

RA190 - Ubiquitin Receptor RPN13/ADRM1 Inhibitor. CAS# 1617495-03-0 60256 KD =53±2 nM) with outstandingRA190, CAS No. 1617495 03 0, is a novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13 ADRM1. It covalently binds to the cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensitive to RA190 via endoplasmic reticulum stress related apoptosis.