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on the production of inflammatory mediators by rheumatoid synovial fibroblasts
a with a Kd of 0
and c-Met-T1010I with IC50 of 3
and completely reduces radiation-induced AKT phosphorylation below the level of control
InChi: InChI=1S/C10H12N4O5
DCC-2036 t N-oxide on the production of inflammatoryDCC 2036, is an orally bioavailable small molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor DCC 2036 binds to and inhibits the Bcr Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand dependent and ligand independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine