GSK-3β Inhibitor II 19296 is a potent and selective

is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2)

C4H6O4/c1-15-20(18

Smiles: ONC(=O)/C=C/C1C=CC(CN(CCO)CCC2=CNC3=CC=CC=C23)=CC=1

1 and 10 μM) improves cell survival of rat neonatal cardiomyocytes compared to vehicle-treated cells

5-trihydroxyoxan-2-yl]methoxy}-6-({[(2S

GSK-3β Inhibitor II 19296 is a potent and selectiveIC50: 390 nM for GSK 3 GSK 3 Inhibitor II is a GSK 3 inhibitor. Glycogen Synthase Kinase 3 (GSK 3), a protein serine kinase, is implicated in the hormonal control of various regulatory proteins. A number of substrates have been identified, which implicates GSK 3 in the regulation of several physiological processes. Moreover, it has been reported that compounds that specifically inhibit GSK 3 activity may be useful in the treatment of diabetes. In