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InChiKey: KHZOJCQBHJUJFY-UHFFFAOYSA-N
Smiles: CN1C2=CC(=CC=C2C(=O)OC1=O)[N+]([O-])=O
ATP-competitive and orally active PKC inhibitor
including angiogenesis
PF-4136309 inhibits hERG potassium current with an IC50 of 20 μM
TEW-7197 - a potent ALK5 inhibitor. CAS# 1352608-82-2 60420 InChiKey: KHZOJCQBHJUJFY-UHFFFAOYSA-NTEW 7197, CAS No. 1352608 82 2, is a potent ALK5 inhibitor. TEW 7197 showed potent in vivo anti metastatic activity, indicating its potential for use as an anti cancer therapy. EW 7197 inhibits TGF Smad signaling. EW 7197 abrogates TGF 1 induced tumor cell migration and invasion. EW 7197 inhibits breast cancer metastasis to the lung. EW 7197 prolongs the life span of BALB c 4T1 mice via inhibition of EMT. EW 7197 inhibits metastasis and enhances the
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