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PubMed Central PMCID: PMC4171582
but also displays marked antiproliferative effects in cell lines with HER2 expressed weakly with IC50 of 53 nM
PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies
Bantscheff M
PI-103 is a potent
Fluo-3AM Catalog No.:M8072-2 PubMed Central PMCID: PMC4171582Fluo 3AM(Fluo 3 pentaacetoxymethyl ester) is a calcium indicator that exhibit an increase in fluorescence upon binding Ca2+; used to image the spatial dynamics of Ca2+ signaling, in flow cytometry experiments involving photoactivation of caged chelators, second messengers, and neurotransmitters, and for cell based pharmacological screening. Product information CAS Number: 121714 22 5 Molecular Weight: 1129. 85 Formula: C51H50Cl2N2O23 Synonym: Fluo 3