BI-882370 evodopa 10bR)-8-chloro-4-methyl-1H

10bR)-8-chloro-4-methyl-1H

CAS Number: 65141-46-0

known as D and L

an active component of Chaetomium globosum

Smiles: CC(NC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(N)CC(O)=O)C(O)=O

BI-882370 evodopa 10bR)-8-chloro-4-methyl-1HBI 882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG out (inactive) conformation of the BRAF kinase. BI 882370 (BI 882370) inhibits the oncogenic BRAFV600E mutant, the WT BRAF and CRAF kinases with IC50s of 0. 4, 0. 8, and 0. 6 nM, respectively. BI 882370 also inhibits SRC family kinases. Product information CAS Number: 1392429 79 6 Molecular Weight: 569. 67 Formula: