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TNF-α Antagonist III
Smiles: CC1C=CC(=CC=1)S(=O)(=O)OCCOCCOCCOCCOC
InChiKey: YYLKKYCXAOBSRM-JXMROGBWSA-N
InChi: InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39
(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0
ELN-441958 Catalog No.:M21309-C TNF-α Antagonist IIIELN 441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR 90 cells with Ki of 0. 26 nM. ELN 441958 is highly selective for B1 over B2 receptors, and >500 2000 fold selective for the B1 over opioid receptor. IC50 value: 0. 26 nM (Ki)Target: B1 Receptorin vitro: ELN 441958 is a novel small molecule bradykinin B1 receptor antagonist, based on the inhibition of agonist induced increases in