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RS-127445 also blocked 5-HT-evoked contraction of rat isolated stomach fundus (pA2 = 9
InChi: InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H
Michelson D
PI3K-alpha (IC50=0
3)4)35-26(38)11-9-7-5-6-8-10-12-27(39)40/h13-16
GANT 58 t metabolite Netupitant N-oxide RS-127445 also blocked 5-HT-evoked contractionGANT58 is a cell permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli mediated gene transactivation (IC50 ~ 5 M in SAG stimulated Shh L2 cells). Product information CAS Number: 64048 12 0 Molecular Weight: 392. 48 Formula: C24H16N4S Synonym: NSC 75503 GANT58 GANT 58 NSC 75503 Chemical Name: 4 [3,4,5 tris(pyridin 4 yl)thiophen 2 yl]pyridine Smiles:
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