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10(7):4081-4089
Batinic-Haberle I
79 µM respectively
BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264
reducing tumor burden and extends survival in lymphoma pdx models
Nirogacestat dihydrobromide - CAS# 1962925-29-6 ant metabolite N-desmethyl Netupitant 10(7):4081-4089Nirogacestat dihydrobromide (PF 3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective secretase inhibitor with an IC50 of 6. 2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor dependent cancers. Product information CAS Number: 1962925 29 6 Molecular Weight: 651. 47 Formula: C27H43Br2F2N5O