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SB-743921 (1
PubMed Central PMCID: PMC4421799
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
3Caffeoylquinate
has many biological and pharmacological properties
TW-37 Catalog No.:M7872-2 SB-743921 (1TW 37 is a small molecule inhibitor of Bcl 2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. TW 37 induces cell growth inhibition and S phase cell cycle arrest, with regulation of several important cell cycle related genes like p27, p57, E2F 1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch 1, Jagged 1, and its
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