MTX-211 RD0539 Smiles: C[C@]12C[C@@H](C3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@]2(O)C(C)=O)C1=CC=C(C=C1)N(C)C

Smiles: C[C@]12C[C@@H](C3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@]2(O)C(C)=O)C1=CC=C(C=C1)N(C)C

InChi: InChI=1S/C20H26Cl2O2/c1-11(2)16-14(21)10-13-12(17(16)22)6-7-15-19(13

Tbk/ikk inhibitor compounds and uses thereof

3 nM and 1

Epub 2012 Jun 19

MTX-211 RD0539 Smiles: C[C@]12C[C@@H](C3[C@@H](CCC4=CC(=O)CCC4=3)[C@@H]1CC[C@]2(O)C(C)=O)C1=CC=C(C=C1)N(C)CMTX 211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. Product information CAS Number: 1952236 05 3 Molecular Weight: 478. 33 Formula: C20H14Cl2FN5O2S Chemical Name: N (2 chloro 5 {4 [(3 chloro 4 fluorophenyl)amino]quinazolin 6 yl}pyridin 3 yl)methanesulfonamide Smiles: CS(=O)(=O)NC1=CC(=CN=C1Cl)C1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1 InChiKey: GUYKCXXNIKKSBC UHFFFAOYSA N InChi: InChI=1S C20H14Cl2FN5O2S c1