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Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10
Russell JL
CAN-15-0817
InChi: InChI=1S/C21H27N3O3/c1-15(2)23-13-18(25)14-27-19-9-3-6-16-8-5-11-24(20(16)19)21(26)17-7-4-10-22-12-17/h3-4
Smiles: CC1C=NC(=CC=1)C1C=CC(C)=CN=1
OSI-930 penem monohydrate Treating a panel of 17OSI 930 is a selective thiophene derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI 930 inhibits stem cell factor receptor (c Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed