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Smiles: CN1CCN(CC1)C1=CC(NC2CCOCC2)=C(C=C1)C(=O)NC1=NNC2=CC=C(CC3C=C(F)C=C(F)C=3)C=C21
with a mean IC50 of 230 nM
Molecular Weight: 452
177(4):1067-1079
Molecular Weight: 326
JHU 37160 - CAS# 2369979-68-8 60202 Smiles: CN1CCN(CC1)C1=CC(NC2CCOCC2)=C(C=C1)C(=O)NC1=NNC2=CC=C(CC3C=C(F)C=C(F)C=3)C=C21JHU 37160, CAS No. 2369979 68 8, is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25 fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1 expressing neurons, and increases hM3Dq stimulated locomotion in rats
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