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InChi: InChI=1S/C22H20N2O5S/c1-17(25)24(30(27
is a potent protein kinase CK2 inhibitor
Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1
Methyl β-D-glucoside
and Disease
A-366 044SB069 InChi: InChI=1S/C22H20N2O5S/c1-17(25)24(30(27A 366 is a potent, highly selective, peptide competitive histone methyltransferase G9a inhibitor with IC50s of 3. 3 and 38 nM for G9a and GLP (EHMT1), respectively. A 366 shows >1000 fold selectivity over 21 other methyltransferases. A 366 is also a potent, nanomolar inhibitor of the Spindlin1 H3K4me3 interaction (IC50=182. 6 nM). A 366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the
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