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transformation
CAS Number: 1675201-83-8
is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM
as well as many other biological processes involving SIRT1
(2013) MBio
PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid transformationPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.
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