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Quantification of the amount of soluble and insoluble (RIPA-extractable) Tau relative to total Tau levels reveals a significant reduction in aberrantly-folded
Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM)
Tectoridin induces estrogenic effect
14bS)-3-(acetyloxy)-4
93 L/kg in rats
MIRA-1 idinium bromide Quantification of the amount ofMIRA 1 is a maleimide derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline regulated mutant p53 (IC50 = 10 M in vitro). 1 Treatment of tumor cells with MIRA 1 induces p21, MDM2 and PUMA in a mutant p53 dependent manner. At a concentration of 5 10 mg kg, MIRA 1, alone or in combination with dexamethasone , arrested tumor growth in a mouse
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