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Isoamyl 4-methoxycinnamate
4]triazin-4(3H)-one
inhibition of DNA repair
Solubility: Soluble in DMSO (up to 25mg/mL)
1072959-67-1
ETP-46321 Size:Solid 10 mg Isoamyl 4-methoxycinnamateETP 46321 is a potent and orally bioavailable PI3K , inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP 46321 PK PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K Ras(G12V) oncogenic mutation. Treatment with ETP 46321
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