ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 mean tumor numbers

mean tumor numbers

918633-87-1

1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1

InChiKey: QASFUMOKHFSJGL-LAFRSMQTSA-N

Smiles: CCOC(=O)C1C=CC(=CC=1)N1NC(=O)/C(=C/C2=CC=C(O2)[N+]([O-])=O)/C1=O

ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 mean tumor numbersITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling