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Formula: C17H16N4O
which consists of four pyrrole rings
the solution was aged 48h at 4-8 ℃
Smiles: C[C@H](O)C(O)=O
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6
Tankyrase Inhibitors (TNKS) 22 halin Formula: C17H16N4OTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis