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catalyzes the first two reactions in the production of leukotrienes from arachidonic acid (AA): oxygenation of AA to 5-HPETE and further dehydration to leukotriene A4 (LTA4)
InChiKey: AEOCXXJPGCBFJA-UHFFFAOYSA-N
Smiles: OC(=O)CC1CC2=CC=C(C=C2N1S(=O)(=O)C1=CC(=CC=C1)C(F)(F)F)C1=CC(F)=CC(=C1)OC(F)F
It has IC50 < 0
PubMed Central PMCID: PMC5114414
NDI-091143 Catalog No.:M32341-C catalyzes the first two reactionsNDI 091143 is a potent and high affinity human ATP citrate lyase (ACLY) inhibitor with an IC50 of 2. 1 nM (ADP Glo assay), a Ki of 7. 0 nM and a Kd of 2. 2 nM. NDI 091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate. Product information CAS Number: 2375840 87 0 Molecular Weight: 453. 84 Formula: C20H14ClF2NO5S Chemical Name: methyl