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Celastrol significantly inhibits the proteasomal chymotrypsin activity in PC-3 cells in a concentration-dependent manner
making hFAS an attractive metabolic target for the treatment of cancer
CAS Number: 847949-51-3
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PMID: 26236920
Lycorine - CAS# 476-28-8 2171 Celastrol significantly inhibits the proteasomalLycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15. 24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases. Product information CAS Number: 476 28 8 Molecular Weight: 287. 31 Formula: C16H17NO4