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OptoBI-1 is a photochromic TRPC3 agonist
Formula: C18H16NNaO5
c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met
Fevipiprant demonstrates a favorable safety profile
SAR407899 (1
R1498 do-tri-(carboxyethoxymethyl)-methane OptoBI-1 is a photochromic TRPC3R1498 is a multi target kinase inhibitor with anti angiogenic and anti proliferative activities. R1498 mainly targets targets such as Aurora kinase and VEGFR2, which are associated with tumor development. R1498 showed moderate in vitro growth inhibition in a variety of tumor cells, with IC50 values in the micromolar range. R1498 showed anti tumor efficacy superior to sorafenib in a variety of gastric cancer and hepatocellular carcinoma xenograft