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Ilginatinib hydrochloride shows potent inhibitory activity against cell lines JAK2V617F or MPLW515L mutations or the TEL-JAK2 fusion gene (expressing a constitutively activated JAK2) with IC50 of 11-120 nM
) respectively
InChi: InChI=1S/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H
InChiKey: HHMCHRRZMCHLLA-PYINPHMPSA-N
Smiles: CC(=O)C1C=CC(=CC=1)N1CCN(CC1)C(=O)C1=CC2OCOC=2C=C1
WAY 207024 dihydrochloride Size:Contact [email protected] for quotation Ilginatinib hydrochloride shows potent inhibitoryWAY 207024 dihydrochloride is a potent gonadotropin releasing hormone receptor (GnRH R) antagonist with IC50 values of 12 and 71 nM for human and rat GnRH receptors, respectively . GnRH R is a member of the G protein coupled receptor (GPCR) family. Activation of the receptor by binding of gonadotropin releasing hormone causes the release of leuteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary gland and they in