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19 149 PMID: 32127666
N-[4-[2-methoxyethyl(methyl)amino]phenyl]-2-phenyl-5-(trifluoromethyl)-1
InChiKey: AEQDJSLRWYMAQI-UHFFFAOYSA-N
InChi: InChI=1S/C19H28O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14
InChiKey: VDOSWXIDETXFET-UHFFFAOYSA-N
Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride 19 149 PMID: 32127666Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP competitive Polo like kinase 1 (PLK1) inhibitor with an IC50 of 0. 87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. Product information
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