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AGN 194310 has been revealed to potently inhibit the colony formation by ITS+-grown cell lines with IC50 values of 16 ± 5nM for LNCaP cells
Formula: C28H33N5O4S
Smiles: CCC(=O)NC[C@@H]1C[C@H]1C1C=CC=C2OCCC=12
CAS Number: 480-66-0
1448347-49-6
N-(3-pyridyl)-Indomethacin amide ulathromycin A AGN 194310 has been revealedN (3 pyridyl) Indomethacin amide is a reversible, potent and selective COX 2 inhibitor . Cyclooxygenase (COX) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX 1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX 2 is inducible and
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