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As dysregulation of the UPR has been implicated in a variety of cell degenerative and neoplastic disorders
(2012) Stem Cell Res
1 µM final concentration in vitro and in cellular assays
PMID: 19696185
5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate
BMS-708163 (Avagacestat) - γ-Secretase Inhibitor. CAS# 1146699-66-2 B-PNP As dysregulation of the UPRBMS 708163 (Avagacestat), CAS No. 1146699 66 2, is a potent, selective and orally bioavailable secretase inhibitor with an IC50 of 0. 3 nM for APP cleavage. It is 190 fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS 708163 decreased CSF A40 and A42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg. Product information CAS
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