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SMARCA4 and PBRM1 in MV-4-11 cells
43(4):307-312
8400 pmol/g) and Tmax (≤0
Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=O
possesses strong antioxidant and cardioprotective properties
Fotemustine cycline (hyclate) SMARCA4 and PBRM1 in MV-4-11Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1 guanine and N3 cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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