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9 x 10(-9)M) and decreased ERK1/2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1]
83280-65-3
and survivin)
InChiKey: CDKIEBFIMCSCBB-CALJPSDSSA-N
Ro3280 - CAS# 1062243-51-9 Catalog No.:M10301-10 9 x 10(-9)M) and decreasedRO3280, also known as Ro5203280, is a potent and selective PLK 1 inhibitor with excellent in vitro cellular potency. RO3280 showed strong antitumor activity in xenograft mouse models. he 50% inhibitory concentration (IC50) of RO3280 for acute leukemia cells was between 74 and 797 nM. The IC50 of RO3280 in primary acute lymphocytic leukemia (ALL) and AML cells was between 35. 49 and 110. 76 nM and 52. 80 and 147. 50 nM, respectively. RO3280 induced
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