BG45 - HDAC3 Inhibitor. CAS# 926259-99-6 Catalog No.:M60266-10S Specificity studies have shown that

Specificity studies have shown that it has no activity on GLP-2

Ropelle ER

Chemical Name: 4-(2-aminoethoxy)-N2

InChi: InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7

CC1N(CC2=CN=CC=N2)C2=C(C(=O)C3=CC=CC=C3C2=O)[N+]=1CCOC

BG45 - HDAC3 Inhibitor. CAS# 926259-99-6 Catalog No.:M60266-10S Specificity studies have shown thatBG45, CAS No. 926259 99 6, is a potent, selective and cell permeable HDAC3 inhibitor. It inhibits HDAC3 with IC50 of 289 nM. It has IC50 of 2. 0 M, 2. 2 M and >20 M for HDAC1, HDAC2, and HDAC6 in cell free assays, respectively. BG45 triggers significant MM cell growth inhibition via apoptosis, evidenced by caspase and poly (ADP ribose) polymerase cleavage. BG45 alone and in combination with bortezomib triggers significant tumor growth inhibition in