Tyk2-IN-7 ogladine 2ClH/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23

2ClH/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23

Scand J Gastroenterol

CAS Number: 188260-50-6

with a Ki of 3 nM

6 nM against rmPD-L1 and rmPD-L2 respectively

Tyk2-IN-7 ogladine 2ClH/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23Tyk2 IN 7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki. app of 0. 00053 M and 0. 00007 M, respectively. Tyk2 IN 7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2 JAK1 JAK2 kinase domain. Tyk2 IN 7 (Compound 48) provides robust inhibition in a mouse IL 12 induced IFN pharmacodynamic model as well as efficacy in an IL 23 and IL 12 dependent mouse colitis