PXS-5120A 8784 inhibition at 24 hours (51%-78%)

inhibition at 24 hours (51%-78%) is almost comparable with that seen at 4 hours

Compound II-25

24 hours) results in complete attenuation of IL-17A secretion in a concentration-dependent manner with an IC50 of 60 nM in HUT78 cells

7-²H₄)pyrazolo[1

Smiles: C[C@@H]1O[C@@H](OC2C=C3OC(=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)C(=O)C3=C(O)C=2)C2C=CC(O)=CC=2)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

PXS-5120A 8784 inhibition at 24 hours (51%-78%)PXS 5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase like 2 3 (LOXL2 3) with anti fibrotic activity. PXS 5120A is >300 fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8. 4) over LOXL (pIC50 of 5. 8). Product information CAS Number: 2125955 70 4 Molecular Weight: 481. 97 Formula: C22H25ClFN3O4S Chemical Name: 1 [(2Z) 4 amino 2 fluorobut 2 en 1 yl] 3 [3 (dimethylsulfamoyl)phenyl] 2 methyl 1H indole 5 carboxylic acid