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Sildenafil citrate significantly increases ICP and ICP/BP but shows no significant effect on BP compared with vehicle
(S)-(+)-Dimethindene maleate I-906 Sildenafil citrate significantly increases ICP(S) (+) Dimethindene maleate, an enantiomer, is a potent M2 selective muscarinic receptor antagonist (pA2 = 7. 86 7. 74; pKi = 7. 78). (S) (+) Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6. 83 6. 36; pKi = 7. 08), the M3 (pA2 = 6. 92 6. 96; pKi = 6. 70) and the M4 receptors (pKi = 7. 00), respectively. (S) (+) Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7. 8). Product information CAS Number:
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