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ENMD-1198 (0-5 μM
such as bone marrow mononuclear cells (BMMCs)
The bioavailability was 50% and 30% in rats and dogs
Smiles: C(NC1=NC2=CC=CC=C2C(NCC2C=CC=CC=2)=N1)C1C=CC=CC=1
enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis
Sotorasib - CAS# 2296729-00-3 roquinol ENMD-1198 (0-5 μMSotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. Product information CAS Number: 2296729 00 3 Molecular Weight: 560. 59 Formula: C30H30F2N6O3 Synonym: AMG 510 Chemical Name: 6 fluoro 7 (2 fluoro 6 hydroxyphenyl) 1 [4 methyl 2 (propan 2 yl)pyridin 3 yl] 4 [2 methyl 4 (prop 2 enoyl)piperazin 1 yl] 1H, 2H pyrido[2, 3 d]pyrimidin 2 one, (1R) Smiles: