![A 438079 417 N-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]prop-2-enamide](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10018_1621561188.gif?v=1621561189)
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N-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]prop-2-enamide
2-d]pyrimidin-6-yl]methyl]piperidin-4-yl]propan-2-ol
with an IC50 of 92 nM
Smiles: CC(C)(C)NC(=O)NC1=NC2=NC(N)=NC=C2C=C1C1C=C(C=C(C=1)OC)OC
InChi: InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H
A 438079 417 N-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]prop-2-enamideA 438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A 438079 partially but significantly prevented the 6 OHDA induced depletion of striatal DA stores. P2X7R inhibitor A 438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure induced neuronal death in the neocortex. Blockade of P2X(7) receptors
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