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is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride
NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor
Molecular Weight: 784
Formula: C29H31F3N6O2
Epub 2008 Oct 18
NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride is more convenient to incorporateTAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF IR with potential anticancer activity. TAE226 can block FAK and IGF IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration dependent decrease in cellular proliferation with an associated G(2) cell cycle