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It is potent in most cancer cell lines
PubMed PMID: 23244871
Smiles: CC(=O)OCOC(=O)C1=CC2=C(C=C1)C(=O)OC12C2=CC=C(C=C2OC2=CC(=CC=C12)B1OC(C)(C)C(C)(C)O1)OCOC(C)=O
InChi: InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9
774549-97-2
Necrostatin-1 Size:Solid 2 mg It is potent in mostNecrostatin 1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin 1 functions as an allosteric inhibitor of the death domain receptor associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin 1 does not present any perturbation of the Fas TNFR triggered canonical apoptosis cascade. Necrostatin 1 inhibits RIP1
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