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is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway
InChiKey: ZGUSBCDCZNBNQT-UHFFFAOYSA-N
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment
InChi: InChI=1S/C13H20N4O7/c14-16-15-4-6-22-8-10-23-9-7-21-5-3-13(20)24-17-11(18)1-2-12(17)19/h1-10H2
CAS Number: 754240-09-0
XAV939 - Wnt Antagonist. CAS# 284028-89-3 size:10mg solid is activated upon DNA damageXAV939, CAS No. 284028 89 3, is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly ADP ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic
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