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InChi: InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H
Metcalf JP
[Epub ahead of print] PubMed PMID: 20525876
Brain-penetrant LSD1 inhibitors can block memory consolidation
32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20
CPI-637 - CAS# 1884712-47-3 60010 InChi: InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7HCPI 637, CAS No. 1884712 47 3, is a potent and selective CBP EP300 bromodomain inhibitor. The biochemical potency of CPI 637 translated well into cells (CBP BRET EC50 = 0. 3 M). CPI 637 demonstrated a >700 fold selectivity over the BET family of bromodomains (BRD4 IC50 = 11. 0 0. 6 M). CPI 637 inhibits MYC expression in AMO 1 cells (EC50 = 0. 60 M). CBP and EP300 are highly homologous, bromodomain containing transcription coactivators involved in
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